2024
1. Zhang H#, Wang Y#, Hu ZW#, Wu YW, Chen N, Zhu YM, Yu YS, Heng-Yu Fan *, Wang HN*. Zygotic Splicing Activation of the Transcriptome is a Crucial Aspect of Maternal-to-Zygotic Transition and Required for the Conversion from Totipotency to Pluripotency. Advanced Science. 2024 Feb 2:e2308496. doi: 10.1002/advs.202308496. 
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2. Wang WJ#, Wu YK#, Liu SY#, Chen L*, Wu HB*, Fan HY*. NAT10-mediated mRNA N4-acetylcytidine modifications in mouse oocytes constitute a checkpoint of ovarian follicle development. Science Bulletin. 2024 Sep 19:S2095-9273(24)00670-4. doi: 10.1016/j.scib..pdf
3. Wu YW#, Deng ZQ#, Rong Y, Bu GW, Wu YK, Wu X, Cheng H, Fan HY*. RNA surveillance by the RNA helicase MTR4 determines volume of mouse oocytes. Developmental Cell. 2024 Oct 4:S1534-5807(24)00537-9. doi: 10.1016/j.devcel..pdf
4. Jiang ZY#, Wu YK#, Deng ZQ, Chen L, Zhu YM, Yu YS, Wu HB*, Fan HY*. PCBP1/2 and TDP43 Function as NAT10 Adaptors to Mediate mRNA ac4C Formation in Mammalian Cells. Advanced Science.2024 Nov 18:e2400133. doi: 10.1002/advs.202400133. .pdf
2022
1. Yu Jiang#, Fei Huang#, Lu Chen#, Jia-Hui Gu# ,Yun-Wen Wu, Meng-Yan Jia, Zhen Lin, Yong Zhou, Yan-Chu Li, Chao Yu, Ming-Han Tong, Li Shen *, Heng-Yu Fan *, Qian-Qian Sha *. Genome-wide map of R-loops reveals its interplay with transcription and genome integrity during germ cell meiosis. Journal of advanced research. 2022 Nov14;S2090-1232(22)00245-4. doi: 10.1016/j.jare.2022.10.016. .pdf
2. Jue Zhang# , Shuai-Bo Pi#, Nan Zhang, Jing Guo, Wei Zheng, Lizhi Leng, Ge Lin*, Heng-Yu Fan *. Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation. Nature Communications. 2022 Nov 4;13(1):6621. doi: 10.1038/s41467-022-34427-x..pdf
3. Xing-Xing Dai#, Shuai-Bo Pi#, Long-Wen Zhao, Yun-Wen Wu, Jing-Ling Shen, Song-Ying Zhang, Qian-Qian Sha*, Heng-Yu Fan*. PABPN1 functions as a hub in the assembly of nuclear poly(A) domains that are essential for mouse oocyte development. Science Advances. 2022 Oct 28;8(43): eabn9016. doi: 10.1126/sciadv.abn9016. .pdf
4. Hua Zhang#, Jun-Chao Jiang#, Yun-Wen Wu, Yuan-Song Yu, Hua-Nan Wang*, Nai-Zheng Ding*, Heng-Yu Fan*.The RNA ligase RNA terminal phosphate cyclase B regulates mRNA alternative splicing and is required for mouse oocyte development and maintenance.Development. 2022 Oct 1;149(19):dev200497. doi: 10.1242/dev.200497..pdf
5. Yan Rong#, Ye-Zhang Zhu#, Jia-Li Yu, Yun-Wen Wu, Shu-Yan Ji, Yong Zhou, Yu Jiang, Jin Jin, Heng-Yu Fan*, Li Shen*, Qian-Qian Sha*. USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation. Nucleic Acids Research. 2022 Jun 10;50(10):5599-5616. doi: 10.1093/nar/gkac468..pdf
6. Yun-Wen Wu#, Sen Li#, Wei Zheng#, Yan-Chu Li#, Lu Chen, Yong Zhou, Zuo-Qi Deng, Ge Lin, Heng-Yu Fan*, Qian-Qian Sha*. Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte aging. Nature Communications. 2022 Jun 9;13(1):3191. doi: 10.1038/s41467-022-30928-x..pdf
7. Lu Chen#, Wen-Jing Wang#, Qiang Liu#, Yu-Ke Wu#, Yun-Wen Wu, Yu Jiang, Xiu-Quan Liao, Fei Huang, Yang Li, Li Shen, Chao Yu, Song-Ying Zhang, Li-Ying Yan, Jie Qiao*, Qian-Qian Sha*, Heng-Yu Fan*. NAT10-mediated N4-acetylcytidine modification is required for meiosis entry and progression in male germ cells. Nucleic Acids Research. 2022 Jul 8; gkac594. doi: 10.1093/nar/gkac594..pdf
8. Yu-Ke Wu, Heng-Yu Fan*. Revisiting ZAR proteins: the understudied regulator of female fertility and beyond. Cell Mol Life Sci. 2022 Jan 24;79(2):92. doi: 10.1007/s00018-022-04141-4..pdf
9. Zhi-Yan Jiang, Heng-Yu Fan*. Five questions toward mRNA degradation in oocytes and preimplantation embryos: When, who, to whom, how, and why? Biol Reprod. 2022 Jan 29; ioac014. doi: 10.1093/biolre/ioac014.pdf.
2021
1. Long-Wen Zhao, Ye-Zhang Zhu, Yun-Wen Wu, Shuai-Bo Pi, Li Shen, Heng-Yu Fan*. Nuclear poly(A) binding protein 1 (PABPN1) mediates zygotic genome activation-dependent maternal mRNA clearance during mouse early embryonic development.Nucleic Acids Res. 2021 Dec 14; gkab1213. doi: 10.1093/nar/gkab1213.pdf.
2. Xing-Xing Dai#, Zhi-Yan Jiang#, Yun-Wen Wu, Qian-Qian Sha, Yang Liu, Jia-Yi Ding, Wen-Dong Xi, Jing Li, Heng-Yu Fan*.CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development.Cell Rep. 2021 Nov 16;37(7):110007. doi: 10.1016/j.celrep.2021.110007.pdf.
3. Xing-Xing Dai, Yu Jiang, Jia-Hui Gu, Zhi-Yan Jiang, Yun-Wen Wu, Chao Yu, Hao Yin, Jue Zhang, Qing-Hua Shi, Li Shen, Qian-Qian Sha*, Heng-Yu Fan*. The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis. Advanced Science. 2021, Mar. 16, doi: org/10.1002/advs.202003636..pdf
4. Yin-Li Zhang#, Wei Zheng#, Peipei Ren, Huiling Hu, Xiaomei Tong, Shuo-Ping Zhang, Xiang Li, Haichao Wang, Jun-Chao Jiang, Jiamin Jin, Weijie Yang, Lanrui Cao, Yuanlin He, Yerong Ma, Yingyi Zhang, Yifan Gu, Liang Hu, Keli Luo, Fei Gong, Guang-Xiu Lu, Ge Lin*, Heng-Yu Fan*, Song-ying Zhang*.Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation.EMBO Mol Med. 2021 Dec 7;13(12):e14887. doi: 10.15252/emmm.202114887. Epub 2021 Nov 15.pdf.
5. Qian-Qian Sha#, Ye-Zhang Zhu#, Yunlong Xiang, Jia-Li Yu, Xiao-Ying Fan, Yan-Chu Li, Yun-Wen Wu, Li Shen*, Heng-Yu Fan*. Role of CxxC-finger protein 1 in establishing mouse oocyte epigenetic landscapes. Nucleic Acids Res. 2021 Mar 18;49(5):2569-2582. doi: 10.1093/nar/gkab107.pdf.
6. Jun-Chao Jiang, Hua Zhang, Lan-Rui Cao, Xing-Xing Dai, Long-Wen Zhao, Hong-Bin Liu, Heng-Yu Fan*. Oocyte Meiosis-Coupled Poly(A) Polymerase α Phosphorylation and 2 Activation Trigger Maternal mRNA Translation in Mice. Nucleic Acids Res. 2021 Jun 4;49(10):5867-5880. doi: 10.1093/nar/gkab431..pdf
7. Long-Wen Zhao, Heng-Yu Fan*. Revisiting poly(A)-binding proteins: Multifaceted regulators during gametogenesis and early embryogenesis. Bioessays. 2021 Apr 8;e2000335. doi: 10.1002/bies.202000335..pdf
2020
1. Lan-Rui Cao, Jun-Chao Jiang, Heng-Yu Fan*.Positive Feedback Stimulation of Ccnb1 and Mos mRNA Translation by MAPK Cascade During Mouse Oocyte Maturation.Frontiers in Cell and Developmental Biology. 2020 Nov 13;8:609430. doi: 10.3389/fcell.2020.609430. eCollection 2020..pdf
2. Qian-Qian Sha#, Wei Zheng#, Yun-Wen Wu, Sen Li, Lei Guo, Shuoping Zhang, Ge Lin*, Xiang-Hong Ou*, Heng-Yu Fan*. Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans.Nature Communications. 2020 Oct 1;11(1):4917. doi: 10.1038/s41467-020-18680-6..pdf
3. Qian-Qian Sha, Jue Zhang, Heng-Yu Fan*. Function and Regulation of Histone H3 Lysine-4 Methylation During Oocyte Meiosis and Maternal-to-Zygotic Transition. Frontiers in Cell and Developmental Biology. 09 October 2020. https://doi.org/10.3389/fcell.2020.597498..pdf
4. Long-Wen Zhao#, Ye-Zhang Zhu#, Hao Chen, Yun-Wen Wu, Shuai-Bo Pi, Lu Chen, Li Shen, Heng-Yu Fan*. PABPN1L Mediates Cytoplasmic mRNA Decay as a Placeholder During the Maternal-To-Zygotic Transition. EMBO Reports. 2020 Jun 17; e49956.doi: 10.15252/embr.201949956..pdf
5. Yu Jiang#, Hui-Ying Zhang#, Zhen Lin#, Ye-Zhang Zhu, Chao Yu, Qian-Qian Sha, Ming-Han Tong*, Li Shen*, Heng-Yu Fan*. CXXC Finger Protein 1-mediated Histone H3 lysine-4 Trimethylation Is Essential for Proper Meiotic Crossover Formation in Mice. Development. 2020 Mar17;147(6): dev183764. doi: 10.1242/dev.183764. .pdf
2019
1. Sha QQ#, Zhu YZ#, Li S, Jiang Y, Chen L, Sun XH, Shen L*, Ou XH*, Fan HY*. Characterization of zygotic genome activation-dependent maternal mRNA clearance in mouse. Nucleic Acids Res. 2019 Nov28. pii: gkz1111. doi: 10.1093/nar/gkz1111..pdf
2. Rong Y#, Ji SY#, Zhu YZ, Wu YW, Shen L, Fan HY*.ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation. Nucleic Acids Res. 2019 Oct 10. pii: gkz863. doi: 10.1093/nar/gkz863..pdf
3. Sha QQ, Jiang Y, Yu C, Xiang Y, Dai XX, Jiang JC, Ou XH, Fan HY*.CFP1-dependent histone H3K4 trimethylation in murine oocytes facilitates ovarian follicle recruitment and ovulation in a cell-nonautonomous manner.Cell Mol Life Sci. 2019 Nov 1. doi: 10.1007/s00018-019-03322-y..pdf
4. Zhang J#, Zhang YL#, Zhao LW#, Pi SB, Zhang SY, Tong C, Fan HY*.The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation. Cell Mol Life Sci. 2019 Sep 6. doi: 10.1007/s00018-019-03280-5..pdf
5. Sha QQ, Zhang J, Fan HY*. A story of birth and death: mRNA translation and clearance at the onset of Maternal-to-Zygotic transition in mammals. Biology of Reproduction,2019 Jan 31. doi: 10.1093/biolre/ioz012..pdf
6. Liu HB, Muhammad T, Guo Y, Li MJ, Sha QQ, Zhang CX, Liu H, Zhao SG, Zhao H, Zhang H, Du YZ, Sun K, Liu K, Lu G, Guo XJ, Sha J, Fan HY, Gao F, Chen ZJ.RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation. Advanced Science. 2019 May 24;6(15):1900295. doi: 10.1002/advs.201900295..pdf
7. Liu Y#, Zhao LW#, Shen JL, Fan HY*, Jin Y*.Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development.Sci Rep. 2019 Apr 18;9(1):6278. doi: 10.1038/s41598-019-42179-w..pdf
2018
1. Sha QQ#, Yu JL#, Guo JX#, Dai XX, Jiang JC, Zhang YL, Yu C, Ji SY, Jiang Y1, Zhang SY, Shen L, Ou XH, Fan HY*. CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte. EMBO Journal, 2018, 37(24). pii: e99333, doi:10.15252/embj.201899333.pdf
2. Zhang YL#, Zhao LW#, Zhang J#, Le R, Ji SY, Chen C, Gao Y, Li D, Gao S, Fan HY*. DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. EMBO Journal, 2018,37(18) :e98981, doi: 10.15252/embj.201898981.pdf
3. Sha QQ#, Dai XX#, Jiang JC#, Yu C#, Jiang Y, Liu J, Ou XH, Zhang SY, Fan HY*. CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes. Nature Communications, 2018,9(1):3477. doi:10.1038/s41467-018-05930-x..pdf
4. Zhang J#, Zhang YL#, Zhao LW#, Guo JX, Yu JL, Ji SY, Cao LR, Zhang SY, Shen L, Ou XH, Fan HY* . Mammalian nucleolar protein DCAF13 is essential for ovarian follicle maintenance and oocyte growth by mediating rRNA processing. Cell Death & Differenciation, 2018, doi:10.1038/s41418-018-0203-7.pdf
5. Dai XX#, Jiang JC#, Sha QQ, Jiang Y, Ou XH, Fan HY*. A combinatorial code for mRNA 3'-UTR-mediated translational control in the mouse oocyte.Nucleic Acids Res, 2018, doi:10.1093/nar/gky971..pdf
6. Zhang Q, Shao J, Fan HY, Yu C. Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis. Communication Biology, 2018, 21(1):147. doi: 10.1038/s42003-018-0154-z..pdf
2017
1. Liu XM, Zhang YL, Ji SY, Zhao LW, Shang WN, Li D, Chen Z, Tong C, Fan HY*. Mitochondrial function regulated by mitoguardin-1/2 is crucial for ovarian endocrine functions and ovulation. Endocrinology, 2017, 158:3988-3999..pdf
2. Ji SY, Liu XM, Li BT, Zhang YL, Liu HB, Zhang YC, Chen ZJ, Liu J, Fan HY*. The polycystic ovary syndrome-associated gene Yap1 is regulated by gonadotropins and sex steroid hormones in hyperandrogenism-induced oligo-ovulation in mouse. Mol Human Reprod, 2017, 23(10): 698-707.
3. Yu C, Fan X, Sha QQ, Wang HH, Li BT, Dai XX, Shen L, Liu J, Wang L, Liu K, Tang F, Fan HY*. CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes. Cell Rep. 2017, 20(5):1161-1172..pdf
4. Xu YW, Cao LR, Wang M, Xu Y, Wu X Liu J, Tong C, Fan HY*. Maternal DCAF2 is crucial for maintenance of genome stability during the first cell cycle in mice. Journal of Cell Science,2017, 130(19):3297..pdf
5. Sha QQ, Dai XX, Dang Y, Tang F, Liu J, Zhang YL, Fan HY*. A MAPK cascade couples maternal mRNA translation and degradation to meiotic cell cycle progression in mouse oocytes. Development, 2017 Feb 1;144(3):452-463..pdf
6. Bo-Tai Li, Chao Yu, Ying Xu, Sheng-Bing Liu, Heng-Yu Fan* and Wei-Wei Pan. TET1 inhibits cell proliferation by inducing RASSF5 expression. Oncotarget, 2017, 8(49):86395..pdf
2016
1. Yu C, Ji SY, Sha QQ, Dang YJ, Zhou JJ, Zhang YL, Liu Y, Wang ZW, Hu BQ, Sun QY, Sun SC, Tang FC, Fan HY*. BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes. Nat Struct & Mol Biol. 2016 May; 23(5):387-394..pdf
2. Yu C, Ji SY, Dang YJ, Sha QQ, Yuan YF, Zhou JJ, Yan LY, Qiao J, Tang FC, Fan HY*. Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse. Cell Res. 2016 Mar; 26(3):275-87..pdf
3. Zhang YP, Liu XM, Bai J, Tian XJ, Zhao XC, Liu W, Duan XY, Shang WN, Fan HY* and Tong C. Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis. Molecular Cell, 2016, 61(1):111.
4. Liu XM, Zhang YP, Ji SY, Li BT, Tian XJ, Li DL, Tong C, and Fan, HY*. Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions.Oncotarget, 2016, 7(2):1155-1167..pdf
1. Yu C, Ji SY, Sha QQ, Sun QY, Fan HY*. CRL4-DCAF1 Ubiquitin E3 Ligase Directs Protein Phosphatase 2A Degradation to Control Oocyte Meiotic Maturation. Nature Communications. 2015 Aug 18. doi: 10.1038/ncomms9017.pdf
2. Zhang YL, Liu XM, Ji SY, Sha QQ, Zhang J, Fan HY*. ERK1/2 Activity Is Dispensable for Oocyte Growth but Is Required for Meiotic Maturation and Pronuclear Formation in Mouse. Journal of Genetics and Genomics. 2015 Aug 23,doi:10.1016/j.jgg.2015.07.004.pdf
3. Yu C, Xu YW, Sha QQ, Fan HY*. CRL4-DCAF1 is Required in Activated Oocytes for Follicle Maintenance and Ovulation. Mol Hum Reprod. 2015 Feb; 21(2):195-205..pdf
4. Yin-Li Zhang, Kang-Ping Guo, Shu-Yan Ji, Xiao-Man Liu, Pilin Wang, Jie Wu, Li Gao, Tian-Qi Jiang, Ting Xu and Heng-Yu Fan*. Development and characterization of a novel long-acting recombinant follicle stimulating hormone agonist by fusing Fc to an FSH-β subunit. Human Reproduction, 2015, 31(1):169..pdf
2014
1. Yin-Li Zhang, Yan Xia, Chao Yu, JoAnne S. Richards, Junping Liu and Heng-Yu Fan*. CBP-CITED4 is required for luteinizing hormone-triggered target gene expression during ovulation. Molecular Human Reproduction, 2014, 20(9):850-60..pdf
2013
1. Yu C, Zhang YL, Pan WW, Li XM, Wang ZW, Ge ZJ, Zhou JJ, Cang Y, Tong C, Sun QY, Fan HY*. CRL4VPRBP/DCAF1 is crucial for female fertility by regulating TET activities in oocytes and zygotes. Science 2013, 342:1518-1521
2. Zhang YL, Yu C, Ji SY, Li XM, Zhang YP, Zhang D, Zhou D, and Fan HY*. DNA topoisomerase II-β prevents follicle atresia in ovarian granulosa cells that are hyper-sensitive to genotoxic chemotherapeutic drugs. Molecular Endocrinology, 2013 27(10):1678-1691
3. Wang ZW, Ma XS, Ma JY, Luo YB, Lin F, Wang ZB, Schatten H, Fan HY, Sun QY. Laser microbeam-induced DNA damage inhibits cell division in fertilized eggs and early embryos. Cell Cycle, 2013, 12(20).
4. Pan WW, Zhou JJ, Xu Y, Guo LJ, Yu C, Zhou D, Song FZ, Fan HY*. CRL4CDT2/DCAF2 ubiquitin E3 ligase as a potential chemotherapeutic target for ovarian surface epithelial cancer. J Biol Chem, 2013, 288(41):29680-29691
5. Li XM, Yu C, Wang ZW, Zhang YL, Liu XM, Sun QY and Fan HY. DNA topoisomerase II is dispensable for oocyte meiotic resumption but is essential for meiotic chromosome condensation and separation. Biology of Reproduction, 2013 89(5): 1–11
6. Li Q, He H, Zhang YL, Li XM, Guo X, Huo R, Bi Y, Li J, Fan HY*, Sha J*. Phosphoinositide 3-kinase p110δ Mediates Estrogen- and FSH-Stimulated Ovarian Follicle Growth. Mol Endocrinol. 2013, 27(9):1468-1482
7. Yu C, Zhang YL, Fan HY*. Selective Smad4 knockout in ovarian preovulatory follicles results in multiple defects in ovulation. Mol Endocrinol. 2013 27(6):966-978
8. Pan WW, Yi F, Cao L, Liu XM, Shen Z, Bu Y, Xu Y, Fan HY，Song F. DAXX silencing suppressesmouse ovarian surface epithelial cell growth by inducing senescence and DNA damage. Gene, 2013, 526(2):287-294
9. Pan WW, Zhou JJ, Liu XM, Xu Y, Guo LJ, Yu C, Shi QH, Fan HY*. Death domain-associatedprotein DAXX promotes ovarian cancer development and chemoresistance. J Biol Chem, 2013. 288(19):13620-13630
10. Qiu Z, Liu M, Chen Z, Shao Y, Pan H, Wei G, Yu C, Zhang L, Li X, Wang P, Fan HY, Du B, Liu B, Liu M, Li D. High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases. Nucleic Acids Res. 2013 41(11): e120
11. Huang L, Wang ZB, Jiang ZZ, Hu MW, Lin F, Zhang QH, Luo YB, Hou Y, Zhao Y, Fan HY, Schatten H, Sun QY. Specific disruption of Tsc1 in ovarian granulosa cells promotes ovulation and causes progressive accumulation of corpora lutea. PLoS One. 2013;8(1):e54052
Before 2012
1. Fan HY, Liu Z, Mullany LK, Richards JS. Consequences of RAS and MAPK activation in the ovary: The good, the bad and the ugly. Mol Cell Endocrinol. 2012 5;356(1-2):74-9.
2. Richards JS, Fan HY, Liu Z, Tsoi M, Laguë MN, Boyer A, Boerboom D. Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene 2012 Mar 22;31(12):1504-20
3 Mullany LK, Fan HY, Liu Z, White LD, Marshall A, Gunaratne P, Anderson ML, Creighton CJ, Xin L, Deavers M, Wong KK, Richards JS. Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo.Oncogene 2011, 30, 3522–3536
4. Fan HY, Liu Z, Johnson PF, Richards JS. CCAAT/Enhancer binding proteins (C/EBP)-α and -β are essential for ovulation, luteinization and the expression of key target genes. Molecular Endocrinology, 2011, 25(2): 253-268
5. Noma N, Kawashima I, Fan HY, Fujita Y, Kawai T, Tomoda Y, Mihara T, Richards JS, and Shimada M. LH-induced neuregulin 1 (NRG1) type III transcripts control granulosa cell differentiation and oocyte maturation. Molecular Endocrinology, 2011 (1):104-16
6. Fan HY, O’connor A, Shitanaka M, Shimada M, Liu Z, Richards JS. Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses luteinizing hormone-mediatedovulation and luteinization. Molecular Endocrinology, 2010, 24(8):1529-1542
7. Liu Z, Fan HY, Wang Y, Richards JS. Targeted disruption of MAPK14 (p38MAPK alpha) in granulosa cells and cumulus cells causes cell specific and compensatory changes in gene expression profiles that maintain fertility in vivo. Molecular Endocrinology, 2010 24(9):1794-804
8. Fan HY, Richards JS. Physiological and pathological actions of RAS in the ovary. Molecular Endocrinology, 2010,24:286-298
9. Fan HY, Liu Z, Paquet M, Wang J, Lydon JP, DeMayo FJ, Richards JS. Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells. Cancer Research, 2009, 69:6463-6472
10. Fan HY, Liu Z, Shimada M, Sterneck E, Johnson PF, Hedrick SM, Richards JS. MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility. Science, 2009, 324:938-941. (Comment in: Science, 2009, 324:938-941. New England Journal of Medicine, 2009, 361:718-719)
11. Sun Y, Kucej M, Fan HY, Yu H, Sun QY, Zou H. Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner. Cell, 2009, 137:123-132.
12. Liu Z, de Matos DG, Fan HY, Shimada M, Palmer S, Richards JS. IL6: a potent regulator of the mouse cumulus cells-oocyte complex expansion process. Endocrinology, 2009, 150:3360-3368
13. Liu Z, Rudd MD, Hernandez-Gonzalez I, Gonzalez-Robayna I, Fan HY, Zeleznik AJ, Richards JS. Genes in sterol/steroid and lipid biosynthetic pathways are targets of FSH and FOXO1 regulation in granulosa cells: evidence from cells expressing mutant forms of FOXO1.Molecular Endocrinology, 2009 23:649-661.
14. Laguë MN, Paquet M, Fan HY, Kaartinen MJ, Chu S, Jamin SP, Behringer RR, Fuller PJ, Mitchell A, Doré M, Huneault LM, Richards JS, Boerboom D. Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression. Carcinogenesis, 2008, 29(11):2062-2072.
15. Fan HY, Liu Z, Cahill N, Richards JS. Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells. Molecular Endocrinology, 2008, 22(9):2128-2140. (Comment in Nature Medicine, 2008, 11:1192-1193.)
16. Fan HY, Shimada M, Liu Z, Cahill N, Noma N, Wu Y, Gossen J, Richards JS. Selective expression of KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulation. Development, 2008, 135:2127-2137.
17. Wayne CW, Fan HY, Cheng X, and Richards JS. FSH-induces multiple signaling cascades: evidence that activation of SRC, RAS and the EGF receptor are critical for granulosa cell differentiation. Molecular Endocrinology, 2007, 21:1940-1957.
18. Fan HY, Sun QY, Zou H. Regulation of separase in meiosis: separase is activated at the metaphase I-II transition in Xenopus oocytes during meiosis. Cell Cycle, 2006, 10:198-204
19. Fan HY, Huo LJ, Schatten H, Chen DY, Sun QY. Protein kinase C and MAPK cascade in mouse cumulus cells: crosstalk and effect on meiotic resumption of oocyte. Biology of Reproduction, 2004, 70:1178-1187
20. Fan HY, Sun QY. Involvement of mitogen-activated protein kinase Cascade during oocyte maturation and fertilization in mammals. Biology of Reproduction, 2004, 70(3):535-547
21. Fan HY, Tong C, Teng CB, Lian L, Li SW, Yang ZM, Chen DY, Schatten H, Sun QY. Characterization of Polo-like kinase-1 in rat oocytes and early embryos implies it’s functional roles in the regulation of meiotic maturation and cleavage. Molecular Reproduction and Development, 2003 65:318-329
22. Fan HY, Huo LJ, Meng XQ, Zhong ZS, Hou Y, Chen DY, Sun QY. Involvement of calcium/calmodulin-dependent protein kinase II (CaMKII) in the meiotic maturation and activation of pig oocytes. Biology of Reproduction, 2003, 69:1552-1564
23. Fan HY, Tong C, Lian L, Li SW, Gao WX, Cheng Y, Chen DY, Schatten H, Sun QY. Characterization of ribosomal S6 protein kinase p90rsk during meiotic maturation and fertilization in pig oocytes: MAPK-associated activation and localization. Biology of Reproduction, 2003, 68:968-977
24. Tong C, Fan HY, Lian L, Li SW, Chen DY, Schatten H, Sun QY. Polo-like kinase 1 is a pivotal regulator of micrutubule assembly during mouse oocyte meiotic maturation, fertilization, and early embryonic mitosis. Biology of Reproduction, 2002, 67:546-554
25. Fan HY, Li MY, Tong C, Chen DY, Xia GL, Song XF, Schatten H, Sun QY. Inhibitory effects of cAMP and protein kinase C on meiotic maturation and MAP kinase phosphorylation in porcine oocytes. Molecular Reproduction and Development, 2002, 63: 480-487
26. Fan HY, Tong C, Li MY, Lian L, Chen DY, Schatten H, Sun QY. Translocation of classical protein kinase C (cPKC) isoforms in porcine oocytes: implications of PKC involvement in the regulation of nuclear activity and cortical granule exocytosis. Experimental Cell Research, 2002, 277:183-191
27. Liang CG, Su YQ, Fan HY, Schatten H and Sun QY. Mechanisms regulating oocyte meiotic resumption: roles of mitogen-activated protein kinase. Molecular Endocrinology, 2007, 21, 2037-2055
28. Tong C, Fan HY, Li SW, Chen DY, Schatten H, Song XF, Sun QY. Effects of MEK inhibitor U0126 on meiotic progression in mouse oocyte: microtuble organization, asymmetric division and metaphase II arrest. Cell Research, 2003, 13:375~383
29. Huo LJ, Fan HY, Zhong ZS, Schatten H, Chen DY, Sun QY. Involvement of ubiquitin-proteasome pathway in mouse oocyte meiotic maturation, fertilization and early embryonic cleavage. Mechanisms of Development, 2004 121(10):1275-1287
30. Huo LJ, Fan HY, Liang CG, Yu LZ, Zhong ZS, Schatten H, Chen DY, Sun QY. Regulation of ubiquitin-proteasome pathway on pig oocyte meiotic maturation and fertilization. Biology of Reproduction, 2004, 71(3):853-862
31. Cheng Y, Fan HY, Wen DC, Tong C, Zhu ZY, Lei L, Sun QY, Chen DY. Asynchronous cytoplast and karyoplast transplantation reveals that the cytoplasm determines the developmental fate of the nucleus in mouse oocytes. Molecular Reproduction and Development, 2003 65:278~282
32. Yao LJ, Fan HY, Tong C, Chen DY, Sun QY. Polo-like kinase-1 in porcine oocyte meiotic maturation, fertilization and early embryonic mitosis. Cellular and Molecular Biology, 2003, 49(3):399-405
33. Quan HM, Fan HY, Meng XQ, Huo LJ, Chen DY, Schatten H, Yang PM, Sun QY. Effects of PKC activation on the meiotic maturation, fertilization, and early embryonic development of mouse oocytes. Zygote, 2003, 11 (4):329-337
34. Meng XQ, Fan HY, Zhong ZS, Zhang G, Li YL, Chen DY, Sun QY. Localization of gamma-tubulin in mouse eggs during meiotic maturation, fertilization, and early embryonic development. Journal of Reproduction and Development, 2004, 50 (1):97-105.
35. Huo LJ, Yu LZ, Liang CG, Fan HY, Chen DY, Sun QY. Cell cycle-dependent subcellular localization of cyclin B1, phosphorylated cyclin B1 and p34cdc2 during oocyte meiotic maturation and fertilization in mouse. Zygote. 2005, 13(1):45-53.
36. Fan HY, Tong C, Chen DY, Sun QY. Roles of MAP kinase signaling pathway in meiosis of oocytes. Chinese Science Bulletin, 47:1157~1162
37. Fan HY, Tong C, Chen DY, Sun QY. Roles of protein kinase C in meiotic maturation and fertilization of oocytes. Progress in Natural Science, 2003, 13:401-406
38. 范衡宇，佟超，陈大元，孙青原：蛋白激酶在卵母细胞减数分裂成熟和受精中的作用。 生物化学与生物物理学报，2002，34: 259-265
39. 范衡宇，佟超，李满玉，孙青原：用激光共聚焦显微术在小鼠卵母细胞中检测蛋白激酶C。生物化学与生物物理进展，2001, 28: 900-903
40. 范衡宇，佟超，孙青原：核糖体S6蛋白激酶p90rsk与卵母细胞减数分裂。生物化学与生物物理进展，2002，29: 506-509
41. 范衡宇，孟小倩，霍立军，佟超，陈大元，孙青原. Detection of spindle-associated proteins in mammalian oocytes by confocal microscopy. 生物化学与生物物理进展, 2004, 31（1）: 54-58
42. 范衡宇，佟超，李世文，陈大元，孙青原：Microtubule organization during in vitro development of rat oocytes. 生物化学与生物物理进展，2002, 29 (5): 708-713
43. 范衡宇，霍立军，孙青原：Roles of calmodulin-dependent protein kinase II in meiotic maturation and fertilization of oocytes. 生物化学与生物物理进展，2003, 30 (2) 171-174
44. 范衡宇，白玉妍，杨增明：胚泡着床窗口的分子调控。生物化学与生物物理进展，2001, 28:11-16
45. Li MY, Fan HY, Tong C, Chen DY, Xia GL, Sun QY. Mitogen-activated protein kinase regulates cell cycle progression in pig oocytes and fertilized eggs. Chinese Science bulletin, 2002, 47: 843-847
46. 霍立军，范衡宇，陈大元，孙青原. 卵母细胞减数分裂和受精过程中MAPK和MPF的作用和相互调节.自然科学进展, 2004,14: 256-261
47. 白玉妍，范衡宇，杨增明：同源盒基因与哺乳动物生殖。 生物化学与生物物理进展，2001, 28: 329-332
48. 范衡宇，佟超， 李世文，陈大元，孙青原：蛋白激酶C在小鼠卵母细胞成熟和受精中的作用。实验生物学报，2003, 36(1): 37-42
49. 范衡宇，杨增明：乙醇对小鼠着床前胚胎体外发育的影响。 动物学报，2001, 47(1): 85-88
50. 范衡宇，杨增明：催产素及其受体与哺乳动物的生殖。 动物学报，2001, 47(4):453-458
51. 范衡宇，佟超，孙青原：丝裂原活化蛋白激酶（MAPK）信号通路的研究进展。动物学杂志, 2002, 37: 98-102
52. 范衡宇，佟超，孙青原：丝裂原活化蛋白激酶（MAPK）信号通路与受精。 生命的化学，2001，21(4): 308~310
53. 范衡宇：与“implantation”相关的几个概念的讨论。 细胞生物学杂志，2001, 23: 230-231
54. 佟超，范衡宇，陈大元，孙青原：Parthenogenetic activation of mouse eggs induced by cycloheximide is calcium-dependent and can be blocked by okadaic acid. 动物学报, 2002, 48: 749-753
55. 佟超，范衡宇，李满玉，陈大元，孙青原：Polo like激酶在细胞分裂中的作用研究进展。生理科学进展，2002，33: 45-47
56.霍立军，范衡宇，陈大元，孙青原：泛素-蛋白水解酶信号通路在卵母细胞减数分裂和受精中的作用。细胞生物学杂志， 2003, 25(2):73-77
57.范衡宇，杨增明：前列腺素及其受体与哺乳动物的生殖。生理科学进展，2000, 31(1): 75-78