报告题目：Activity-based sensing: leveraging chemical reactivity for selective bioimaging
报告人：Christopher J. Chang 教授 
主持人：林世贤 研究员
时   间：2024年5月17日（周五）上午10点
地   点：校友楼紫金港厅
报告人简介：

       Christopher J. Chang教授2002年在美国麻省理工学院获得博士学位，现任加州大学伯克利分校化学和分子细胞生物学学院冠名教授。他是活性传感技术（activity-based sensing）的奠基人和开拓者，将活性传感技术发展成为通用检测平台，用于活体、实时、原位检测过渡金属、活性氧和一碳代谢物，并在神经变性、癌症和代谢紊乱疾病中，揭示了金属和氧化还原信号的独特作用机制。Chang教授还是人工光合作用的研究专家，利用生物学的设计理念，开发了用于二氧化碳捕获和以及转化氮/磷循环的分子电催化剂。

       Chang教授的研究在Science（4篇），Nature（2篇），Nature大子刊等国际顶级学术期刊发表通讯论文100多篇，他引5万多次，h-index 120。曾获得ACS Bader Award (2024), Humboldt Research Award (2020), Sackler Prize (2019), Fellow of American Academy of Arts and Sciences (2017), Fellow of Royal Society of Chemistry (2015), Blavatnik National Award (2015), ACS Eli Lilly Award (2012), ACS Cope Scholar Award (2010)等重磅荣誉。

讲座摘要：

Traditional strategies for developing selective imaging reagents rely on molecular recognition and static lock-and-key binding to achieve high specificity. We are advancing an alternative approach to chemical probe design, termed activity-based sensing, in which we exploit inherent differences in chemical reactivity as a foundation for distinguishing between chemical analytes that are similar in shape and size within complex biological systems. This presentation will focus on activity-based sensing to visualize dynamic fluxes of metal ions, reactive oxygen species, and reactive carbon species, along with activity-based proteomics probes to characterize targets of single-atom signaling. In one example, we have identified a new paradigm termed metalloallostery, where metal binding beyond active sites at allosteric exosites in proteins can regulate fundamental behaviors, such as eating and sleeping.