肖睦

时间:2019年03月28日 威廉体育唯一官网:975

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肖 睦 博士

威廉(中国)副教授
电话:86-571-88981540
Email: Mu_Xiao@zju.edu.cn 

教育背景
 
1997-2001          武汉大学生命科学学院        生物学基地班        学士
2001-2006          武汉大学病毒国家实验室      生物化学             博士
2006-2011          美国罗切斯特大学(University of Rochester, NY)     博士后
工作经历
 
2011-今     威廉(中国) 副教授 博士生导师
研究方向
 
研究非编码RNA以及其结合蛋白在干细胞分化和癌细胞发生中的作用机制。
代表性论文
 
1.   Guowei Wu*, Mu Xiao*, Chunxin Yang, Yi-Tao Yu, 2011, U2 snRNA is inducibly pseudouridylated at novel sites by Pus7p and snR81 RNP, Embo J ;30(1):79-89 ( Co-First auther)
2.   Mu Xiao,Chunxing Yang, Peter Schattner, Yi-Tao Yu, 2008, Functionality and substrate specificity of human box H/ACA guide RNAs.RNA 15(1): 176–186.
3.   Mu Xiao, Tingting Li, Xiaoyan Yuan, Yuan Shangand Yi Zhang, 2005, A peripheral element assembles the compact core structure essential for group I self-splicing. Nucleic Acids Research33: 4602-4611.
4.   Mu Xiao, Michael J. Leibowitz and Yi Zhang. 2003, Concerted folding of a Candida ribozyme to the catalytically active structure posterior to a rapid RNA compaction. Nucleic Acids Research 31: 3901-3908. (Cover topic)
5.   Libin Zhang, Mu Xiao, Chen Lu and Yi Zhang. 2005, Fast formation of the P3-P7 pseudoknot: a strategy for efficient folding of the catalytically active ribozyme. RNA 11(1): 59-69.
6.   Yanfei Jiang, Mu Xiao, Ping Yin and Yi Zhang 2006, Monovalent cations use multiple mechanisms to resolve ribozyme misfolding.RNA 12(4):561-566
7.   Jiehua Zhou, Jiangyu Wu, Xiaoxuan Liu, Fanqi Qu, Mu Xiao, Yi Zhang, Laurence Charles, Cheng-cai Zhang and Ling Peng 2006, Cooperative binding and self-assembling behavior of cationic low molecular-weight dendrons with RNA molecules. Org Biomol Chem. 4, 581-5.
8.   Shunji Jia, Fangyan Dai, Di Wu, Xia Lin, Cencan Xing, Yu Xue, Ying Wang, Mu Xiao, Wei Wu, Xin-Hua Feng, Anming Meng, 2012, Protein Phosphatase 4 Cooperates with Smads to Promote BMP Signaling in Dorsoventral Patterning of Zebrafish Embryos. Dev. Cel.22(5): 1065-1078