报告题目： Structural Insights into the Interaction between Bacterial Pathogen and the Host Cell
报告人： Yongqun Zhu, Ph.D.
Research Associate, Howard Hughes Medical Institute (HHMI)
Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center
主持人： 冯新华 教授
时 间： 2011年9月9日（星期五）下午3点
地 点： 医学院综合楼205报告厅
Selected Papers:
1. Yongqun Zhu, Hongtao Li,Chengzu Long, Liyan Hu, Hao Xu, Liping Liu, She Chen,Da-Cheng Wang, and Feng Shao. Structural Insights into the Enzymatic Mechanism of the Pathogenic MAPK Phosphothreonine Lyase. Molecular Cell. 28, 899–913, Dec 14, 2007.
8. Yong-Qun Zhu, De-Yu Zhu, Hong-Xia Lu, Na Yang, Gen-Pei Li, Da-Cheng Wang. Purification and Preliminary Crystallographic Studies of CutC, a Novel Copper Homeostasis Protein from Shigella flexneri. Protein & Peptide Letters. 12, 823-826, 2005.
7. De-Yu Zhu, Yong-Qun Zhu*, Ye Xiang and Da-Cheng Wang. Optimizing Protein Crystal Growth through Dynamic Seeding. Acta Cryst. (2005). D61, 772-775. (*equal contribution)
6. De-Yu Zhu, Yong-Qun Zhu*, Ren-Huai Huang, Ye Xiang, Na Yang, Hong-Xia Lu, Gen-Pei Li, Qi Jin, and Da-Cheng Wang. Crystal Structure of the Copper Homeostasis Protein (CutCm) from Shigella flexneri at 1.7Å Resolution: The First Structure of a New Sequence Family of TIM Barrels. PROTEINS.58:764–768, 2005. (* equal contribution)
5. Yong-Qun Zhu, De-Yu Zhu, Lei Yin, Ying Zhang, Clemens Vonrhein, and Da-Cheng Wang. Crystal Structure of Human Spermidine/Spermine N1-Acetyltransferase (hSSAT): The First Structure of a New Sequence Family of Transferase Homologous Superfamily. PROTEINS. 63:1127–1131, 2006.
4. Qing Yao, Jixin Cui, Yongqun Zhu, Guolun Wang, Liyan Hu, Chengzu Long, Ran Cao, Xinqi Liu, Niu Huang, She Chen, Liping Liu, and Feng Shao. A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle. Proc Natl Acad Sci USA. 2009 Mar 10; 106(10):3716-21.
3. Yongqun Zhu, Liyan Hu, Yan Zhou, Qing Yao, and Feng Shao. Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA. Proc Natl Acad Sci USA. 2010 Mar 9; 107(10):4699-704.
2. Yongqun Zhu, Hongtao Li, Jiayi Wang, Liyan Hu, Yan Zhou, Liping Liu, Feng Shao. Structure of a Shigella effector reveals a new class of ubiquitin ligases. Nature Structural & Molecular Biology. 15(12):1302-8, Dec 2008.
