报告题目：Functional Investigation of Human Diseases by Using Knockout and Transgenic Mice
报告人： 朱大海 教授
中国医学科学院基础医学研究所副所长 &中国协和医科大学基础医学院副院长
主持人： 冯新华 教授
时 间： 2010年11月18日（星期四）下午4点
地 点： 医学院综合楼205报告厅
报告人简介：
朱大海 教授 ，1994年毕业于美国北卡州立大学分子遗传学博士专业，后在美国杜克大学医学院参加博士后研究工作；曾任美国国家卫生研究院助研究员、美国北卡州立大学助教授。现为中国医学科学院基础医学研究所副所长 &中国协和医科大学基础医学院副院长。
研究方向：
从分子、细胞、组织、器官和整体水平，利用基因敲除与转基因小鼠作为模型，开展肌肉发生与代谢在发育生物学和生理学中重要功能的研究，特别是糖尿病和心肌肥大发生发展的系统生物学研究。回国后的研究工作分别发表在J. Biol. Chem.，Cancer Research，Cellular Signaling, Oncogene, BMC Genomics, Cell Research, Gene, Animal Genetics,Journal of Translation Medicine等杂志上。
代表性论文：
1． Tingting Li, Xueya Zhou, Xiaowo Wang, Dahai Zhu, Yong Zhang. Identification and characterization of human snoRNA core promoter. Genomics, Published online 2010.
2． Yong Zhang, Jun Liu, Chunshi Jia, Tingting Li, Rimao Wu, Jie Wang, Ying Chen, Xiaoting Zou, Runsheng Chen, Xiujie Wang and Dahai Zhu. Systematic identification and evolutionary features of Rhesus Monkey snoRNAs. BMC Genomics, Published online 2010
3． Yong Zhang, Jie Wang, Shoujun Huang, Xiaopeng Zhu, Jun Liu, Ning Yang, Rimao Wu, Wei Deng, Geir Skogerbø, Xiu-Jie Wang, Runsheng Chen, Dahai Zhu. Novel Features Uncovered by Systematic Identification and Characterization of Gallus gallus ncRNAs. Nucleic Acids Research, Published online 2009, 1–13,doi:10.1093/nar/gkp704
4． Qi Zheng, Yong Zhang, Ying Chen, Ning Yang, Xiu-Jie Wang and Dahai Zhu. Systematic identification of genes involved in divergent skeletal muscle growth rates of broiler and layer chickens. BMC Genomics, 2009, 10:87.
5． Ming Ji, Qiang Zhang, Jianwei Ye, Xueyan Wang, Wei Yang, Dahai Zhu, Myostatin induces p300 degradation to silence cyclin D1 expression through the PI3K/PTEN/Akt pathway. Cellular Signaling, 2008,1452-1458.
6． Wei Yang, Yong Zhang, Yanfeng Li, Zhenguo Wu and Dahai Zhu. Myostatin induces cytoplasmic cyclinD1 degradation to cause cell cycle arrest through a PI3K-Akt-GSK3 pathway and is antagonized by IGF-1. J. Biol. Chem., 2007.
7． Xujun Ma, Qian Qian, Chuanping Yang, Guifeng Liu and Dahai Zhu, Effect of mouse calcineurin on induction and growth of rice callus transformed by the calcineurin gene. Plant Cell, Tissue and Organ Culture, 2006, 86:1-6.
8． Wei Yang, Yan Chen，Yong Zhang, Xueyan Wang, Ning Yang, and Dahai Zhu，Erk1/2 mitogen-activated protein kinase pathway involves in myostatin-regulated differentiation repression Cancer Research, 2006, 66 (3) 1-7.
